为快速止血和增强再生而设计坚韧的血栓
Engineering tough blood clots for rapid haemostasis and enhanced regeneration

原始链接: https://www.nature.com/articles/s41586-026-10412-y

## 止血材料与生物制造在伤口愈合方面的进展 近期研究集中于开发先进材料以有效促进伤口愈合,特别是解决不可压迫性出血问题。关键领域包括新型止血生物材料——从液体注入粘合剂和藤壶启发型糊剂到壳聚糖基溶液——旨在实现快速血凝,且不依赖于传统的凝血途径。理解血凝块的力学性质,包括弹性及断裂行为,对于优化这些材料至关重要。 除了简单的血凝块形成,研究还探索将生物材料与组织工程策略相结合,利用支架、无支架技术,甚至类器官进行复杂的组织再生。生物制造和生物打印与细胞聚集体结合,在肌肉骨骼组织工程方面正日益受到重视。 创新的方法利用生物正交化学(“点击化学”)对材料性质和细胞相互作用进行动态控制,从而实现具有增强功能的“活体”材料。此外,研究人员正在研究红细胞的独特特性,并设计模拟其力学的材料,以改善粘附性和整体性能。最终目标是创造出坚固、适应性强的生物材料,不仅能促进止血,还能促进完全且功能性的组织修复。

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