碲镉锌:驱动医学“革命”的神奇材料
Cadmium Zinc Telluride: The wonder material powering a medical 'revolution'

原始链接: https://www.bbc.com/news/articles/c24l223d9n7o

## CZT:变革医学影像及其他领域的革命性材料 碲化镉锌(CZT)是一种特殊的材料,因其显著提升成像技术的能力而日益受到重视。伦敦皇家布朗普顿医院最近安装了一台新型CZT肺扫描仪,展示了这一点——它将检查时间从45分钟缩短到15分钟,同时产生高度详细的3D图像,并将辐射暴露降低30%。 全球只有少数几家公司,例如英国Kromek公司,能够制造CZT,因为其复杂的生产过程需要精确对准的晶体生长,耗时数周。除了用于扫描长新冠和肺栓塞等疾病外,CZT还用于X射线望远镜、机场安检,并计划在Diamond Light Source等大型研究机构进行升级。 然而,目前需求超过供应,给需要特定CZT配置的研究人员带来了挑战。尽管如此,CZT在光子探测方面的卓越精度正在推动成像领域的革命,为各种科学和安全应用提供更清晰、更高效的结果。

``` Hacker News新版 | 过去 | 评论 | 提问 | 展示 | 招聘 | 提交登录 镉锌碲:驱动医疗“革命”的神奇材料 (bbc.com) 4点 由 1659447091 1小时前 | 隐藏 | 过去 | 收藏 | 讨论 指南 | 常见问题 | 列表 | API | 安全 | 法律 | 申请YC | 联系 搜索: ```
相关文章

原文

Chris BaraniukTechnology Reporter

Very few organisations can supply cadmium zinc telluride

Lying on your back in a big hospital scanner, as still as you can, with your arms above your head – for 45 minutes. It doesn't sound much fun.

That's what patients at Royal Brompton Hospital in London had to do during certain lung scans, until the hospital installed a new device last year that cut these examinations down to just 15 minutes.

It is partly thanks to image processing technology in the scanner but also a special material called cadmium zinc telluride (CZT), which allows the machine to produce highly detailed, 3D images of patients' lungs.

"You get beautiful pictures from this scanner," says Dr Kshama Wechalekar, head of nuclear medicine and PET. "It's an amazing feat of engineering and physics."

The CZT in the machine, which was installed at the hospital last August, was made by Kromek – a British company. Kromek is one of just a few firms in the world that can make CZT. You may never have heard of the stuff but, in Dr Wechalekar's words, it is enabling a "revolution" in medical imaging.

This wonder material has many other uses, such as in X-ray telescopes, radiation detectors and airport security scanners. And it is increasingly sought-after.

Investigations of patients' lungs performed by Dr Wechalekar and her colleagues involve looking for the presence of many tiny blood clots in people with long Covid, or a larger clot known as a pulmonary embolism, for example.

The £1m scanner works by detecting gamma rays emitted by a radioactive substance that is injected into patients' bodies.

But the scanner's sensitivity means less of this substance is needed than before: "We can reduce doses about 30%," says Dr Wechalekar. While CZT-based scanners are not new in general, large, whole-body scanners such as this one are a relatively recent innovation.

Dr Kshama Wechalekar with the latest scanner at London's Royal Brompton Hospital

CZT itself has been around for decades but it is notoriously difficult to manufacture. "It has taken a long time for it to develop into an industrial-scale production process," says Arnab Basu, founding chief executive of Kromek.

In the company's facility at Sedgefield, there are 170 small furnaces in a room that Dr Basu describes as looking "like a server farm".

A special powder is heated up in these furnaces, turned molten, and then solidified into a single-crystal structure. The whole process takes weeks. "Atom by atom, the crystals are rearranged […] so they become all aligned," says Dr Basu.

The newly formed CZT, a semiconductor, can detect tiny photon particles in X-rays and gamma rays with incredible precision – like a highly specialised version of the light-sensing, silicon-based image sensor in your smartphone camera.

Whenever a high energy photon strikes the CZT, it mobilises an electron and this electrical signal can be used to make an image. Earlier scanner technology used a two-step process, which was not as precise.

"It's digital," says Dr Basu. "It's a single conversion step. It retains all the important information such as timing, the energy of the X-ray that is hitting the CZT detector – you can create colour, or spectroscopic images."

He adds that CZT-based scanners are currently in use for explosives detection at UK airports, and for scanning checked baggage in some US airports. "We expect CZT to come into the hand luggage segment over the next [few] years."

Special furnaces are needed to make CZT

But it's not always easy to get your hands on CZT.

Henric Krawczynski at Washington University in St Louis in the US has used the material before on space telescopes attached to high altitude balloons. These detectors can pick up X-rays emitted by both neutron stars and plasma around black holes.

Prof Krawczynski wants very thin, 0.8mm pieces of CZT for his telescopes because this helps to reduce the amount of background radiation they pick up, allowing for a clearer signal. "We'd like to buy 17 new detectors," he says. "It's really difficult to get these thin ones."

He was unable to source the CZT from Kromek. Dr Basu says his firm has high demand at the moment. "We support many, many research organisations," he adds, "It's very difficult for us to do a hundred different things. Each research [project] needs a very particular type of detector structure."

For Prof Krawczynski, it's not a crisis – he says he might use either CZT that he has from previous research, or cadmium telluride, an alternative, for his next mission.

However, there are bigger headaches at the moment. That upcoming mission was due to fly from Antarctica in December but "all the dates are in flux", says Prof Krawczynski, because of the US government shutdown.

CZT will be used in an upgrade of Diamond Light Source

Many other scientists use CZT. In the UK, a major upgrade of the Diamond Light Source research facility in Oxfordshire – costing half a billion pounds – will improve its capabilities thanks to the installation of CZT-based detectors.

Diamond Light Source is a synchrotron, which fires electrons around a giant ring at nearly the speed of light. Magnets cause these whizzing electrons to lose some energy in the form of X-rays, and these are directed off from the ring in beamlines so that they may be used to analyse materials, for example.

Some recent experiments have involved probing impurities in aluminium while it melts. Understanding those impurities better could help improve recycled forms of the metal.

With Diamond Light Source's upgrade, due to complete in 2030, the X-rays produced will be significantly brighter, meaning that existing sensors would not be able to detect them properly.

"There's no point in spending all this money in upgrading these facilities if you can't detect the light they produce," says Matt Veale, group leader for detector development at the Science and Technology Facilities Council, which is the majority owner of Diamond Light Source.

That's why, here too, CZT is the material of choice.

More Technology of Business
联系我们 contact @ memedata.com