人工智能被用于设计新型病毒
Artificial Intelligence used to design new viruses

原始链接: https://www.bbc.co.uk/news/articles/c5y3j3ngevmo

研究人员实现了一个重要的里程碑:利用人工智能从零开始设计出了具有功能的病毒基因组。虽然病毒并非生命体,但这一突破标志着人类首次通过计算机模型完成了生物学设计。 专家指出,尽管创造复杂的活细胞仍有巨大的跨度——因为即使是最简单的细胞,其基因组也比本研究中所用的噬菌体大 100 倍——但这一成就代表了合成生物学的一个转折点。该技术证明了人工智能能够破译基因组的“语言”并学习进化设计原则,从而为医学开辟了新的疆界。研究人员设想利用人工智能辅助的基因组编写技术来开发先进疗法,包括用于对抗疾病的特异性噬菌体、治疗遗传病的酶以及用于免疫疗法的新型抗体。最终,这项研究为人类能够通过编写生物学方案来应对全球最紧迫的挑战铺平了道路。

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原文

Viruses are not alive and it would take another significant leap for AI to generate living organisms.

The genetic code of the phage is around 5,400 base pairs (letters) long. The smallest genome of a living cell is around 500,000 base pairs. The human genome is three billion base pairs.

Hie says "it would probably be a lot of work, but not impossible" to attempt some simple organisms and they were "definitely interested in working towards" that.

Prof Marc Güell, from the synthetic biology lab at Pompeu Fabra University in Spain, said the study was a "very significant turning point" because for the "first time in history, we are beginning to design biology on a computer".

He said it "allows us to dream of exciting possibilities for tackling humanity's greatest challenges" such as developing phages to tackle disease, enzymes to treat genetic disorders and antibodies that could be used in immunotherapy.

Prof Patrick Cai, chair of synthetic genomics at the Manchester Institute of Biotechnology, said the study was an "important milestone".

"The significance extends far beyond phages – it suggests that genome language models are beginning to learn the design principles encoded by evolution, opening the door to AI-assisted genome writing."

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