We are grateful to our research collaborators at University of Exeter, Broad Institute, Boston Children’s Hospital, Stowers Institute for Medical Research, Harvard University, Memorial Sloan Kettering Cancer Center, Center for Genomic Medicine at Massachusetts General Hospital, and the University of Kansas Medical Center.

This work was done thanks to the contributions of Jun Cheng, Kyle R. Taylor, Lauren Nicolaisen, Joshua Pan, Clare Bycroft, Matteo Perino, Tom Ward, Raina W. Thomas, Natasha Latysheva, Gareth Hawkes, Laura E. Covill, Melanie Weilert, Maile J. Hirschmann, Xi Dawn Chen, Robin N Beaumont, V Kartik Chundru, Michael N Weedon, Simon Bourdareau, Hoyin Chu, Dhavi Hariharan, Thais Kagohara, Lucas Tenório, Yosuke Ushigome, Amanda Stafford, Courtney A. Shearer, Barbara Ikica, Ada Fang, Mouad Naciri, Victoria Johnston, Richard Green, Elisa Lai Hong Wong, Vincent Dutordoir, Anne Mottram, Adam Gayoso, Eirini Arvaniti, Guido Novati, Heidi L. Rehm, Fei Chen, Caleb A. Lareau, Caroline F Wright, Anne O'Donnell-Luria, Julia Zeitlinger, Pushmeet Kohli, Žiga Avsec.

We wish to thank our teammates and collaborators for their technical support, feedback, including Kathryn Tunyasuvunakool, Alexander Karollus, Risha Patel, Francesca Pietra, Alisha Eastep, Doga Fadillioglu, Charlie Taylor, Raphael Aboyeji, Uchechi Okereke, Gemma Gibbs, Olufemi Duduyemi, Juan Mateos-Garcia, Mariana Felix, Sahar Abdulrahman, Antonia Mould, Rachael Tremlett, Chang Yun, Salil Deshpande, Anshul Kundaje, Samantha Bryen, Greg Findlay, Phoebe Dace, Kinga Bujakowska, Emma Sherrill, Aubrie Soucy Verran, Boxun Zhao, Tim Yu, Francesca Pietra, Brendah Namugamba, Cassie Gray, Daniel MacArthur, Lingyi Wang, Marc Mansour, Mohamad Hajjari, Mounica Vallurupalli, Philip Montgomery, Phoebe Dace, Roisin Sullivan, Sam Bryen, Teresa Niccoli,

Finally we wish to thank Evie Gray, Adriana Fernandez Lara, Alex Wilkins, Danielle Breen, Mariana Montes, Inês Ayer, Ryan Smith, Ross West and Gaby Pearl for their expertise in communicating this work.