我的邻居、我和一个伟大原则
My Neighbor, Me, and a Grand Principle

原始链接: https://lastwordonnothing.com/2026/10/19/my-neighbor-me-and-a-grand-principle/

邻居兴奋地告诉作者,化学诺贝尔奖授予了Kagan和Soai,以表彰他们在同手性方面的研究。作者并非化学家,她了解到所有生命的分子都是左手性的,而实验室反应通常会生成两种手性分子。两位获奖者的工作表明,对一种手性微小的初始偏差可通过重复反应被放大,直到只有左手性分子占主导。作者看到了与物理学的相似之处:尽管物质与反物质被等量创造,宇宙仍主要由物质构成,因为微小偏差传播并累积。她将此与自己的“小步”哲学联系起来:小而重复的努力会累积。最后,她凯旋般地、快乐地走着。

Hacker News 列出了来自 lastwordonnothing.com 的《My Neighbor, Me, and a Grand Principle》,由 royalroad 发布,获得 26 点和 5 条评论。评论者称赞其写作的美与人性。一位评论者想知道作者是顺时针还是逆时针行走;另一位回复说,选择一个方向会把她的鞋穿得不均匀。
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原文

The other week I was trudging through laps around the court I live on, and a neighbor yelled across the court, first “HI” and I yelled “HI” right back and then he yelled, “THIS IS THE BEST DAY OF THE YEAR!”

So I asked why it was the best day of the year, and trudged a little closer to hear him better even though he was still yelling, “BECAUSE IT’S THE DAY THE CHEMISTRY NOBEL IS ANNOUNCED.” I’ve known this neighbor since he first moved here, buying his first house, he and his wife having their first baby, starting his first real job, which — relevant to our discussion — was as a young professor of chemistry. Chemistry has always seemed to combine the idiosyncratic rats’-nest of biology and the rigorous theology of physics, and I stay away from it. But I’m a science writer and professionally obliged to be curious, so I trudged a bit closer and asked who won the chemistry Nobel. My neighbor was still yelling. “KAGAN AND SOAI,” pronounced so-aye, “FOR HOMOCHIRALITY,” he yelled, which, I haven’t a clue. And because he’s a scientist to his bones, every atom of him is scientist, he was pleased to tell me, unasked, what homochirality is and how it happens and I went over to where he was standing by his car and listened hard.

He started by telling me all the molecules of life — all the molecules of life? so, everything that life is and does? I didn’t ask — had a handedness, which chemists call chirality. Pretty word, ancient Greek, means “hand,” I sort of knew what chirality meant: the way the molecule twists itself, spirals toward the left or right, I pictured a snail shell, a DNA molecule, a helix. He was getting ahead of me already. Turns out that all the molecules of life — whatever they are — have the same chirality, homochirality, “homo,” also ancient Greek, means “same.” Every amino acid in every protein in every cell twists toward the left, they are all left-handed. But chemical reactions — which are what? I didn’t ask — in the lab, create both left- and right-handed molecules. I wasn’t following his argument 100%, more like 50%, and I know from these links I’m inserting that it’s not this simple. But I did get the bottom line: if both chiralities are created equal, how come we’re all molecularly left-handed?

The Nobel Prize winners figured that out and did the experiment(s). In experiments, it turns out — and this is thoroughly above my pay grade — they could do some magic that life must also have done: they could prejudice the outcome just the least little tiny bit toward the left-handed. And then they could take that outcome with the tiny prejudice and repeat — something or other that’s repeated — and by the time it all comes out in the wash, those tiny prejudices toward the left have added up and accumulated and pretty soon life is only left-handed. The word I’m thinking of is “propagated,” used the way physicists use it: one thing leads to another. A tiny difference in a reaction that gets repeated and repeated just gets bigger and bigger. The prejudice propagates and accumulates.

At least, I think that’s what my neighbor was saying. I didn’t ask because 1) I wouldn’t have understood him without a lot more brain work and I hadn’t had breakfast; and 2) I was interrupted by a blinding epiphany. Which was this ⬇️:

Physicists (different science now, not chemistry, physics) say that when energy turns into matter (E=mc2, only the other way around), like at the beginning of the universe, the big bang, the outcome is split pretty evenly into matter and anti-matter. No, I don’t know what anti-matter is; and yes, I might be dead wrong about this. Anyway physicists’ bottom-line question is: if both kinds of matter are created equally, how come the universe is made only of matter? And their answer is: whenever energy is turning into matter — also no, I don’t have a clue — the outcome has a tiny prejudice against anti-matter and toward matter. And since the universe is large and lasts a long time, that prejudice propagated and accunulated and everything now is only matter. SAME QUESTION, why only left-handedness? why only matter? SAME ANSWER, a prejudice propagated and accumulated. Life and the universe, connected by a principle!

But I was uncertain about my epiphany so I said, “I don’t think this is is the same question and the same answer but somehow the outline of the problem is the same.” And my neighbor said, “No, they’re the same. They’re the same question and the same answer.” He seemed happy about this, maybe a little distracted by the possibility of slippery logic. But he wasn’t as happy as I was.

I KNEW IT! I’ve been saying for years now: if you want to do something and you can’t, you just can’t, do Baby Steps. 500 thank you notes to write? 3 a day. 210 minutes of walking a week? add 2 minutes a day. BABY STEPS ADD UP! PROGRESS PROPAGATES! And now I know that Baby Steps has some pretty hefty backup in physics and chemistry, Nobel-Prize-winning chemistry.

I explained all this to my neighbor but by that time, he needed to do other things and went into his house. I, however, continued my morning laps in triumph and gratitude to the chemistry Nobel, and with a light and happy heart. Baby Steps: Life, the Universe, and Everything.

(And here you thought the answer was 42. Serves you right for trusting a fiction writer.)

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Snail shells with opposite chiralities: Davison A, Chiba S, Barton NH, Clarke B., CC BY 2.5 https://creativecommons.org/licenses/by/2.5, via Wikimedia Commons

Steps: Tcolburn52, CC BY-SA 4.0 https://creativecommons.org/licenses/by-sa/4.0, via Wikimedia Commons

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