研究发现,运动补充剂肌酸对肌肉增长没有影响。
Sports supplement creatine makes no difference to muscle gains, trial finds

原始链接: https://www.unsw.edu.au/newsroom/news/2025/03/sports-supplement-creatine-makes-no-difference-to-muscle-gains-trial-finds

一项由新南威尔士大学领导的新研究挑战了普遍存在的观点,即肌酸补充剂与阻力训练结合能显著促进肌肉生长。这项为期12周的临床试验发表在《营养素》杂志上,发现服用推荐剂量(每日5克)肌酸的参与者与未服用的参与者在瘦肌肉质量增加方面没有显著差异,两组参与者的平均增重均为两公斤。 该研究的资深作者曼迪·哈格斯特罗姆博士认为,之前的研究可能由于方法上的缺陷(例如同时开始补充剂和运动)高估了肌酸的益处,这使得难以分离补充剂的效果。这项试验加入了一个“适应期”,参与者在开始运动计划前一周就开始补充肌酸。虽然肌酸是一种天然化合物,在以往的研究中显示出益处,但这项研究表明,在推荐剂量下,与单独进行阻力训练相比,它可能不会在肌肉生长方面提供可测量的优势。研究人员还提到肌酸可能导致水分滞留,但这需要进一步调查。

Hacker News 上的一个帖子讨论了一项研究,该研究表明肌酸对肌肉增长的影响很小。许多用户对此表示不同意,他们认为肌酸的好处在于能够进行更多组数的训练以及由于 ATP 增加和 pH 值缓冲而使恢复速度加快。他们强调肌酸在短期能量和肌肉水分潴留方面的作用,从而提高运动表现并最终促进肌肉生长。一些用户强调将肌酸与持续的运动和适当的饮食结合起来的重要性。一位用户还指出,最初的研究对象并未达到体育活动指南的要求。虽然有些人承认潜在的水潴留效应,但许多人强调了他们体验到的切实好处,表明个体结果可能会有所不同。
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原文

People hoping to build muscle with the support of a creatine supplement might be disappointed by new research which shows it has little to no effect when taken at the recommended level.  

People who take the popular sports supplement creatine and lift weights do not build muscle any faster than those who do resistance training without the supplement, new research shows.  

A UNSW-led clinical trial that put 54 people through a 12-week resistance training program found no difference between those who took the supplement at the recommended dose and those who did not, the research published in Nutrients shows.

Both groups in the randomised control trial put on an average of two kilograms of lean body mass during the program, which involved three supervised resistance training sessions per week.

“We’ve shown that taking five grams of creatine supplement per day does not make any difference to the amount of lean muscle mass people put on while resistance training,” said senior author Dr Mandy Hagstrom, from UNSW’s School of Health Sciences

“The benefits of creatine may have been overestimated in the past, due to methodological problems with previous studies,” she added. 

Creatine is a naturally occurring compound which supplies energy to muscles. It is produced by the liver, pancreas and kidneys, and found in protein-rich foods. Previous research shows creatine supplements help build muscles, enhance athletic performance, and may even have cognitive benefits. 

However, previous trials have started supplementation and exercise programs on the same day, making it difficult to separate the effect of each on muscle gains, Dr Hagstrom said. They’ve also overlooked the potential for creatine to cause water retention, though more research was needed to confirm this.

So, in this trial, those in the supplement group started on creatine one week before the exercise program began, taking five grams per day, which is at the upper end of the recommended maintenance dose of three to five grams.

“We had what we call a wash-in phase, where half of the participants started taking the supplement, without changing anything else in their daily life, to give their body a chance to stabilise in terms of its response to the supplement,” Dr Hagstrom said. 

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