研究揭示了屏蔽肝病需要多少杯咖啡
Study Reveals How Many Cups Of Coffee Needed To Shield Against Liver Disease

原始链接: https://www.zerohedge.com/food/study-reveals-how-many-cups-coffee-needed-shield-against-liver-disease

一项新的英国生物银行研究表明,无论类型(包括Decaf,Instant和Ground),咖啡消费量提供了对慢性肝病(CLD)的重大保护。研究人员发现,与非咖啡饮用者相比,普通咖啡饮用者患CLD的风险低21%,CLD或脂肪变性的风险降低了20%,CLD的死亡风险低49%。 每天3-4杯观察到最强的保护效果,而地面咖啡(包括浓缩咖啡)显示出最大的影响。咖啡因对促进肝纤维化的A2AA受体的抑制作用可能是一个因素,但脱咖啡因的咖啡点对其他有益的化合物(如氯酸,kahweol和cafestol)的保护作用,在地面咖啡中丰富。这些化合物表现出抗纤维化特性。这项研究加强了以前的发现,将咖啡消费与降低各种CLD结局的风险联系起来。

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原文

Waking up for the London Stock Exchange isn't complete without the daily ritual: fire up the espresso machine, grind those dark roasted Robusta beans, and 30 seconds later—boom—a jolt of caffeine strong enough to skim a dozen Goldman, UBS, and Bank of America notes. But here's the kicker: the morning rocket fuel might be doing a lot more than energizing you for the trading session. 

According to a massive UK Biobank study, coffee—yes, even the decaf, instant, and ground stuff—appears to protect against chronic liver disease (CLD).

"Coffee consumption has been linked with lower rates of CLD, but little is known about the effects of different coffee types, which vary in chemical composition," researchers from the University of Edinburgh Centre for Inflammation Research wrote in the report. 

Here are the key takeaways from the study, which found that compared to non-coffee drinkers, regular coffee drinkers had a

  • 21% lower risk of incident CLD
  • 20% lower risk of CLD or steatosis
  • 49% lower risk of death from CLD

Dose-Response: "The maximal protective effect was seen at around 3–4 cups each day. The findings were robust to excluding events in the first 5 years. Drinkers of decaffeinated, instant, and ground coffee (including espresso) also had lower risks of incident CLD, incident CLD or steatosis, death from CLD, and, to a lesser extent, HCC, with ground coffee (including espresso) having the largest effect," the researchers found. 

Researchers noted, "This study agrees with previous cohort studies that generally report inverse associations between coffee consumption and CLD outcomes, including deranged liver enzymes, fibrosis, cirrhosis, and hepatocellular carcinoma."

Biologically, coffee's protective effect is plausible. Caffeine inhibits the A2aA receptor, which otherwise promotes liver fibrosis. Yet decaffeinated coffee was also protective, pointing to other active compounds like chlorogenic acid, kahweol, and cafestol—especially concentrated in ground coffee. These compounds have shown anti-fibrotic effects in animal studies, suggesting a multifactorial mechanism behind coffee's liver-protective properties.

What better way to armor your liver and support your favorite forward-looking financial news site than by grabbing a bag of our ZeroHedge-approved coffee beans?

Top pick? The dark roast. Bold, unapologetic—just like our headlines.

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