超声正在开启无手术癌症治疗的新时代。
Ultrasound is ushering a new era of surgery-free cancer treatment

原始链接: https://www.bbc.com/future/article/20251007-how-ultrasound-is-ushering-a-new-era-of-surgery-free-cancer-treatment

聚焦超声作为一种有前景的癌症治疗增强手段正在出现,可能同时改善放射疗法和免疫疗法。该技术加热并破坏肿瘤,出乎意料地使肿瘤对免疫系统*更*易于识别——从而使其能够更好地识别和攻击癌细胞。 研究人员认为超声波可以实现较低、危害较小的辐射剂量,同时保持疗效。重要的是,它似乎与免疫疗法具有协同作用,帮助身体的防御系统靶向那些逃避免疫检测的癌症。 未来的研究重点是将这种组合应用于晚期、转移性癌症。最终目标是在单个肿瘤上使用超声波来“揭示”癌症特征,从而引发全身免疫反应,攻击全身的癌细胞——有效地用一次聚焦治疗来治疗多个肿瘤。虽然目前仍处于理论阶段,但这种方法为癌症治疗提供了一种潜在的革命性转变。

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原文
As focused ultrasound heats and damages tumours, it seems to make these tissues more visible to the immune system

"Radiation therapy does cure cancer, but it does also cause a lot of long-term side effects," Sharma says. If its effects can be enhanced thanks to ultrasound-stimulated microbubbles, she says, doctors could theoretically use lower doses to achieve the same treatment effects with fewer devastating side effects. 

Ultrasound also seems to be a good match for immunotherapy, a treatment approach focused on spurring the immune system to fight off cancerous cells that may be dodging or hiding from the body's natural defences.

As focused ultrasound heats and damages tumours, it seems to make these tissues more visible to the immune system – and thus more vulnerable to its defences, says Price, whose research centre is focused on using ultrasound along with immunotherapy. 

A direction for future research, Price says, is determining whether that pairing can work against advanced-stage cancer. Metastatic cancer is much harder to treat than localised disease – when cancer spreads throughout the body, it's no longer enough to remove a single tumour. The holy grail would be that clinicians could someday use ultrasound to coax one tumour out of hiding by breaking it apart, allowing the immune system to pick up on its characteristics and launch a system-wide attack against cancerous cells elsewhere in the body, Price says. This remains to be tested in any kind of trials, but theoretically, doctors could "treat 10, 15, 20 tumours just by treating one tumour", Price says.

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