One day after the FAA issued a Notice to Air Missions (NOTAM), or an alert notifying pilots of potential serious hazards in certain airspace, for the Maiquetía Flight Information Region above Venezula, Reuters reported that the US is poised to launch a new phase of Venezuela-related operations in the coming days, citing four U.S. officials.

Amid a sharp escalation of pressure by the Trump administration on President Nicolas Maduro's government, including proliferating reports of looming action as the US military deployed forces to the Caribbean amid worsening relations with Venezuela, two of the sources said covert operations would likely be the first part of the new action against Maduro, while two US officials told Reuters the options under consideration included attempting to overthrow Maduro.

A senior administration official on Saturday told Reuters that nothing had been ruled out regarding Venezuela.

"President Trump is prepared to use every element of American power to stop drugs from flooding into our country and to bring those responsible to justice," said the official, speaking on the condition of anonymity.

Before the Reuters report, six airlines had already cancelled flights to Venezuela on Saturday after the US aviation regulator warned major airlines of dangers from "heightened military activity" amid a major buildup of American forces in the region, as well as a "potentially hazardous situation" when flying over Venezuela and urged them to exercise caution.

Spain's Iberia, Portugal's TAP, Chile's LATAM, Colombia's Avianca, Brazil's GOL and Trinidad and Tobago's Caribbean have suspended their flights to the country, said Marisela de Loaiza, president of the Venezuelan Airlines Association (ALAV). Panama's Copa Airlines, Spain's Air Europa and PlusUltra, Turkish Airlines, and Venezuela's LASER are continuing to operate flights for now.

The Trump administration has been weighing Venezuela-related options to combat what it has portrayed as Maduro’s role in supplying illegal drugs that have killed Americans. He has denied having any links to the illegal drug trade. 

Maduro, under whose rule Venezuela has experienced crushing hyperinflation and a collapse in its oil production sector amid staggering corruption, has contended that Trump seeks to oust him and that Venezuelan citizens and the military will resist any such attempt. He also has characterized U.S. actions as an effort to take control of Venezuela's oil.

A military buildup in the Caribbean has been underway for months, and Trump has authorized covert CIA operations in Venezuela.

The United States plans on Monday to designate the Cartel de los Soles a foreign terrorist organization for its alleged role in importing illegal drugs into the United States, officials said. The Trump administration has accused Maduro of leading Cartel de los Soles, which he denies.

Washington in August doubled its reward for information leading to Maduro's arrest to $50 million. But U.S. Defense Secretary Pete Hegseth said last week that the terrorist designation "brings a whole bunch of new options to the United States."

Trump has said the upcoming designation would allow the United States to strike Maduro's assets and infrastructure in Venezuela, but he also has indicated a willingness to potentially pursue talks in hopes of a diplomatic solution.

Maduro said earlier this week that the countries' differences should be resolved through diplomacy and that he is willing to hold face-to-face talks with anyone interested. Two U.S. officials acknowledged conversations between Caracas and Washington. It was unclear whether those conversations could impact the timing or scale of potential U.S. operations.

The U.S. Navy's largest aircraft carrier, the Gerald R. Ford, arrived in the Caribbean on November 16 with its strike group, joining at least seven other warships, a nuclear submarine and F-35 aircraft.

U.S. forces in the region so far have focused on counter-narcotics operations, even though the assembled firepower far outweighs anything needed for them. U.S. troops since September have carried out at least 21 strikes on alleged drug boats, killing at least 83 people, mostly in the Caribbean, although vessels in the Pacific Ocean also have been targeted.