In the years leading up to Mary Shelley’s publication of Frankenstein, there was a very public debate in the Royal College of Surgeons between two surgeons, John Abernethy and William Lawrence, on the nature of life itself. Both of these surgeons had links with the Shelleys: Percy had read one of Abernethy’s books and quoted it in his own work and Lawrence had been the Shelleys’ doctor. In this debate, questions were asked about how to define life , and how living bodies were different from dead or inorganic bodies. Abernethy argued that life did not depend upon the body’s structure, the way it was organised or arranged, but existed separately as a material substance, a kind of vital principle, “superadded” to the body. His opponent, Lawrence, thought this a ridiculous idea and instead understood life as simply the working operation of all the body’s functions, the sum of its parts. Lawrence’s ideas were seen as being too radical: they seemed to suggest that the soul, which was often seen as being akin to the vital principle, did not exist either. Lawrence was forced to withdraw the book in which he had published his lectures and resign the hospital post he held, though he was reinstated after publicly denouncing the views he had put forward. The episode showed just how controversial the categories of life and dead had become and provided further inspiration for Mary Shelley’s novel.