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原始链接: https://news.ycombinator.com/item?id=43627917

Hacker News上的一篇讨论围绕着一篇关于细胞线粒体交换及其对健康影响的文章展开。用户探讨了其潜在的应用,范围从提高运动成绩(“线粒体兴奋剂”)到治疗慢性疲劳和精神健康障碍,其理论基础是线粒体功能障碍是许多疾病的根本原因。一些人建议培养和移植线粒体可能是一种解决方案,一位用户推荐了Casey Means博士关于细胞代谢功能障碍的著作《Good Energy》。另一些人则建议专注于优化现有线粒体的环境,以促进健康的裂变和融合,而不是移植。一位用户分享了一个关于线粒体“亲吻和奔跑”动力学的研究所链接,并表达了对使用自身线粒体进行安全“线粒体黑客”以提高运动成绩的希望。还提到了利用这项技术对抗衰老的可能性。


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Cells are swapping their mitochondria. What does this mean for our health? (nature.com)
32 points by pmags 8 hours ago | hide | past | favorite | 8 comments










Fascinating. I wonder if there will soon be a way to culture your mitochondria externally in order to give you extra, maybe it could help with diseases like chronic fatigue.


Mitochondria doping! People are already thinking how to use it for sports performance. https://www.telegraph.co.uk/news/2025/02/14/new-doping-trick...

Beyond athletic performance and chronic fatigue, some neurologists and psychiatrists have recently suggested that every mental disorder (literally, the entire DSM) has a single underlying cause: mitochondrial dysfunction. If that's true, mitochondria transplants could solve the mental health crisis.



Dr Casey Means has a thought provoking book on this subject Good Energy. It’s about how cell metabolic dysfunction could be implicated in a wide range of health conditions.


Re mental health - this is extremely interesting if it turns out to be correct. Thanks for sharing


Why transplant? Mitochondria are constantly fusing and fissioning. Wouldn't it be better to provide mitochondria with a more comfortable environment to ensure they fission?


Off the top of my head, I would imagine transplanting gives more control over the end result.


Several implicit suggestions are made in the article, but I guess the largest application of externally cultivated mitochondria would be to aging.

Here is an article about this (future) technology:

https://pmc.ncbi.nlm.nih.gov/articles/PMC5511681/



We stan a mito story! My old lab discovered some of what we called "kiss and run" dynamics: https://en.wikipedia.org/wiki/Kiss-and-run_fusion

Which had to do with watching live mitos exchange their insides. Very cool stuff, mitos are so important to metabolism and more I hope we see mitohacking, as mentioned by perrygeo. A much safer performance enhancer when it's your own mitos.

Not sure why this is downvoted, but that's HN I guess!







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