A recent Hacker News discussion centered on a study suggesting prolonged sitting, even with exercise, may shrink the brain. Commenters highlighted the diminishing quality of life in extended lifespans due to sedentary lifestyles, arguing that medical advancements prolong physical life while cognitive decline remains unaddressed. Practical advice for combating sedentary effects included incorporating movement throughout the day, such as pull-up bars, short walks, and varied postures. Treadmill desks were suggested as a valuable tool, despite skepticism, to combat fatigue and increase energy. Many emphasized moderation and variety in exercise, diet, and social interaction as the key to overall well-being. Skepticism was voiced about the study's methodology, including concerns about linear regression models, unclear units, and confusing correlation with causation. Some suggested sedentary behavior might be a symptom of cognitive decline rather than the cause.